The Rensselaer Center for Stem Cell Research (RCSCR) was established in 2012 with a NYSTEM award for the construction and operation of a shared-use stem cell research facility. The Stem Cell Research Core provides comprehensive support for basic stem cell research with tissue engineering and regenerative medicine applications. Our state-of-the-art multi-laboratory facility supports collaborative projects involving cell biology, medical engineering, chemical engineering and informatics research. In addition to dedicated tissue culture, incubation and microscopy equipment, the Center provides equipment for hypoxia studies, time lapse and high-content microscopy. Research within the stem cell facility is enhanced by direct collaboration with several neighboring Rensselaer research cores and their staff members, including advanced microscopy, bioimaging, cell biology, biochemistry and animal research.
Dr. Brigitte Arduini is Director of the Center’s Stem Cell Research Core Facility. She received her B.S. in Biology from Cornell University and her Ph.D. in Molecular Genetics from the Ohio State University, studying neural crest development in the zebrafish. As a post-doctoral associate at the Rockefeller University, Brigitte utilized human embryonic stem cells and mammalian embryology to analyze neural crest and paraxial mesoderm formation in the lab of Ali Brivanlou. Prior to joining RPI in August 2012, Brigitte was Director of the Rockefeller University Human Pluripotent Stem Cell Core Facility.
Xie J, Owen T, Xia K, Singh AV, Tou E, Li L, Arduini B, Li H, Wan LQ, Callahan B, Wang C. Zinc Inhibits Hedgehog Autoprocessing: Linking Zinc Deficiency with Hedgehog Activation. J Biol Chem. 2015 290(18):11591-600.
Arduini BL, Brivanlou AH. Modulation of FOXD3 Activity in Human Embryonic Stem Cells Directs Pluripotency and Paraxial Mesoderm Fates. Stem Cells. 2012 Oct;30(10):2188-98.
Warmflash A, Arduini BL, Brivanlou AH. The molecular circuitry underlying pluripotency in embryonic stem cells. Wiley Interdiscip Rev Syst Biol Med. 2012 Sep;4(5):443-56. doi: 10.1002/wsbm.1182.
Arduini BL, Bosse KM, Henion PD. Genetic ablation of neural crest cell diversification. Development. 2009 Jun;136(12):1987-94.
Elizondo MR, Arduini BL, Paulsen J, MacDonald EL, Sabel JL, Henion PD, Cornell RA, Parichy DM. Defective skeletogenesis with kidney stone formation in dwarf zebrafish mutant for trpm7. Curr Biol. 2005 Apr 12;15(7):667-71.