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RCSCR investigators develop novel chip platform for high-throughput drug screening

A new study, “High-Throughput Toxicity and Phenotypic Screening of 3D Human Neural Progenitor Cell Cultures on a Microarray Chip Platform,” is in press at Stem Cell Reports.


Greg Nierode, a PhD candidate in the Howard P. Isermann Department of Chemical and Biological Engineering and lead author, says of the study, “We found that there were differential toxic sensitivities (i.e. cells of one group were more likely to respond adversely compared to cells of the other group) between the undifferentiated and differentiating cells for several compounds. We hope this study elicits increased interest in investigating the differential effects of drugs and chemicals on stem/progenitor cells at different stages of maturation.”

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